Tailored Mobility in a Zeolite Imidazolate Framework (ZIF) Antibody Conjugate**

Zeolitic imidazolate framework (ZIF) hybrid fluorescent nanoparticles and ZIF antibody conjugates have been synthesized, characterized, employed in lateral-flow immunoassay (LFIA). The bright fluorescence of the possibility to tailor their mobility gives a huge potential for diagnostic assays. An enzyme-linked immunosorbent assay (ELISA) with horseradish peroxidase (HRP) as label, proved integrity, stability, dispersibility conjugates, LC-MS/MS provided evidence that covalent link was established between these metal-organic frameworks lysine residues IgG antibodies.